Championship side Cardiff City face the task of ousting holders Chelsea from the FA Cup after the draw was made for the fifth round.
Cardiff went through after a 4 – 2 win over Leicester while Chelsea eased past Preston North End 2 – 0 with goals from Nicolas Anelka and Daniel Sturridge.
There are potentially four all-Premier League ties with Manchester City’s game against Stoke already confirmed.
Wolves or Crystal Palace will take on Aston Villa, Bolton are at home to Tottenham or Leeds and Fulham will welcome Notts County or Wigan.
A tie that will fascinate the neutrals is the South coast derby between Southampton and Portsmouth while elsewhere, Derby host Birmingham in a Midlands clash and Reading take on West Bromwich Albion at the Madejski Stadium meaning there will definitely be a Championship side in the quarter finals this year.
FA Cup 5th round draw
Southampton v Portsmouth
Reading v West Bromwich Albion
Fulham v Notts County or Wigan Athletic
Chelsea v Cardiff City
Bolton Wanderers v Tottenham Hotspur or Leeds United
Derby County v Birmingham City
Manchester City v Stoke City
Wolverhampton Wanderers or Crystal Palace v Aston Villa